TABLE 2.

In vitro activities of telithromycin and eight other antibiotics against viridans group streptococci (n = 77) isolated from blood samples of neutropenic cancer patients by penicillin G susceptibility

Antibiotic	Type of streptococcusa	MIC (μg/ml)b
		Range	50%	90%
Penicillin G	S	≤0.03–0.12	0.06	0.12
	IR	0.25–2	1	2
	HR	4–16	4	8
Erythromycin A	S	≤0.03–>128	0.06	4
	IR	≤0.03–>128	0.5	>128
	HR	≤0.03–>128	2	>128
Cefotaxime	S	≤0.03–1	0.06	0.25
	IR	≤0.03–2	1	2
	HR	1–16	4	8
Clindamycin	S	≤0.03–>128	0.12	0.5
	IR	≤0.03–>128	0.5	>128
	HR	≤0.03–>128	0.12	>128
Vancomycin	S	≤0.25–1	0.5	1
	IR	0.5–1	0.5	1
	HR	0.5–1	0.5	1
Chloramphenicol	S	≤2–8	4	4
	IR	≤2–8	4	8
	HR	≤2–8	4	4
Co-trimoxazole	S	≤0.5–4	≤0.5	4
	IR	≤0.5–8	2	4
	HR	≤0.5–8	4	4
Ciprofloxacin	S	≤0.12–16	2	4
	IR	0.5–8	2	8
	HR	1–>32	4	>32
Telithromycin	S	≤0.03–2	≤0.03	0.06
	IR	≤0.03–0.5	≤0.03	0.25
	HR	≤0.03–2	≤0.03	0.25

^aS, viridans group streptococci (n = 46) susceptible to penicillin G (MIC, ≤0.03 to 0.12 μg/ml); IR, viridans group streptococci (n = 13) intermediately resistant to penicillin G (MIC, 0.25 to 2 μg/ml); HR, viridans group streptococci (n = 18) highly resistant to penicillin G (MIC, ≥4 μg/ml). 

^b50% and 90%, MIC₅₀ and MIC₉₀, respectively.