Table 7.

Stability of cefazolin under different storage conditions.

	Human samples		Rat samples
	mean accuracy [%]	CV [%] (n=3)	mean accuracy [%]	CV [%] (n=3)
	adipose tissue homogenate stability
• bench-top [20°C, 6 h]
LQC	98.1	9.6	100.9	1.8
ULOQ	96.6	1.0	97.8	3.0
• freeze-thaw [−80°C, 3 cycles]
LQC	102.0	0.4	-	-
ULOQ	90.0	3.4	-	-
• long-term [−80°C, 8 weeks]
LQC	92.3	5.5	-	-
ULOQ	97.7	0.9	-	-
	in-filtrate stability
• short-term [10°C, 24 h]
LQC	98.8	2.6	102.9	5.2
ULOQ	99.3	3.5	97.6	1.4
• long-term [−20°C, 12 days]
LQC	-	-	112.4	2.1
ULOQ	-	-	106.0	2.2
	aqueous solutions stability
• stock solution [−20°C, 11 weeks]
LQC	-	-	100.3	4.5
ULOQ	-	-	100.4	4.5
• working solutions [−20°C, 4 weeks]
LQC	-	-	102.7	2.0
ULOQ	-	-	95.9	4.0

LQC = 0.1 μg/mL, ULOQ = 50 μg/mL of cefazolin in adipose tissue homogenate.