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. 2022 Apr 22;5(8):e202101209. doi: 10.26508/lsa.202101209

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© 2022 Li et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 8. — (A) Fasting glucose levels in the plasma of WT and FKO mice fed on regular chow (n = 8 in WT group and n = 5 in FKO group, each point represents a biology replicate, representative of three repeats). Data are represented as mean ± SEM, t test, *P < 0.05. (B) Fasting insulin levels in the plasma of WT and FKO mice fed on regular chow (n = 8 in WT group and n = 5 in FKO group, each point represents a biology replicate, representative of three repeats). Data are represented as mean ± SEM, t test. (C) Blood glucose levels during the glucose tolerance test in WT and FKO mice fed on regular chow (n = 8 in WT group and n = 5 in FKO group). Data are represented as mean ± SEM. t test, *P < 0.05. (C, D) The area under the curve (AUC) from (C) (n = 8 in WT group and n = 5 in FKO group, each point represents a biology replicate). Data are represented as mean ± SEM, t test, *P < 0.05. (E) Blood glucose levels during the insulin tolerance test in WT and FKO mice fed on regular chow (n = 8 in WT group and n = 5 in FKO group, representative of three repeats). Data are represented as mean ± SEM, t test, *P < 0.05. (F) The AUC of (E) (n = 8 in WT group and n = 5 in FKO group, each point represents a biology replicate). Data are represented as mean ± SEM, t test, *P < 0.05. (G) Fasting glucose levels in the plasma of WT and FKO mice fed on HFD (n = 5 in WT group and n = 10 in FKO group, each point represents a biology replicate, representative of three repeats). Data are represented as mean ± SEM, t test, *P < 0.05. (H) Fasting insulin levels in the plasma of WT and FKO mice fed on HFD (n = 5 in WT group and n = 10 in FKO group, each point represents a biology replicate, representative of three repeats). Data are represented as mean ± SEM, t test, *P < 0.05. (I) Blood glucose levels during the glucose tolerance test in the WT and FKO mice fed on HFD (n = 5 in WT group and n = 10 in FKO group, representative of three repeats). Data are represented as mean ± SEM, t test, *P < 0.05, **P < 0.01. (I, J) The AUC of (I) (n = 5 in WT group and n = 10 in FKO group, each point represents a biology replicate). Data are represented as mean ± SEM, t test, **P < 0.01. (K) Blood glucose levels during the insulin tolerance test in WT and FKO mice fed on HFD (n = 5 in WT group and n = 10 in FKO group, representative of three repeats). Data are represented as mean ± SEM, t test, *P < 0.05. (K, L) The AUC of (K) (n = 5 in WT group and n = 10 in FKO group, each point represents a biology replicate). Data are represented as mean ± SEM, t test. (M) WB analysis of pAKT(S473) and AKT in the lysates from the liver of WT and FKO mice fed on HFD. The samples were collected 15 min later after insulin injection via i.p. β-Actin was used as the loading control (n = 3 per group, representative of three repeats). (N) Quantification of the band intensity of pAKT/AKT ratio in (M) (n = 3 per group, each point represents a biology replicate). Data are represented as mean ± SEM, t test, **P < 0.01. (O) WB analysis of pAKT(S473) and AKT in the lysates from the muscle of WT and FKO mice fed on HFD. The samples were collected 15 min later after insulin injection via i.p. β-Actin was used as the loading control (n = 3 per group, representative of three repeats). (O, P) Quantification of the band intensity of pAKT/AKT ratio in (O) (n = 3 per group, each point represents a biology replicate). Data are represented as mean ± SEM, t test, *P < 0.05.

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