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. 2022 Mar 18;298(5):101848. doi: 10.1016/j.jbc.2022.101848

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Glycated αSN seeds aggregation in cells. SH-SY5Y cells with a Tet-Off cassette for regulating the inducible expression of WT αSN were differentiated for 4 days with retinoic acid. Cells were then treated for another 4 days with 100 nM of the various αSN preparations and subjected to immunocytochemistry. The fraction of cells harboring pS129 positive inclusions (B) was quantified (A). Red circles in the inset specified with a number show the samples tested in the experiment. Insets in (A) are identical to Figure 4, A and B and were placed here for a better clarity. Scale bar: 10 μm. Statistical significance was assessed via ANOVA with a post hoc Tukey. ∗p < 0.05. αSN, α-synuclein.