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. 2022 Mar 13;4(1):vdac026. doi: 10.1093/noajnl/vdac026

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© The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Differential expression of genes of in resistant models shows re-activation of SHH pathway in resistant samples. A) RNA-seq analysis of vehicle and resistant samples showing up- (240) and downregulated (283) genes; expression levels of GLI1 (B), GLI2 (C), MYCN (D) and SUFU (E) of vehicle-treated (n = 3) and resistant models (n = 9) do not show differences; F) IPA analysis of pathways increased and decreased in resistant samples compared to vehicle samples does not reveal pathways related to (cancer) cell proliferation or tumor growth.