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. 2022 Mar 13;4(1):vdac026. doi: 10.1093/noajnl/vdac026

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© The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — RNA-seq analysis of short-time treated samples confirms target engagement of Sonidegib. A) RNA-seq analysis of Sonidegib (short time) treated samples showing 17 up- and 105 downregulated genes compared to vehicle-treated samples; B) GSEA shows that HH signaling pathway is upregulated in vehicle and resistant samples compared to short-time treated samples; expression levels of GLI1 (C), GLI2 (D), MYCN (E), SUFU (F) show downregulation in short-time treated samples compared to vehicle samples; G) IPA analysis of pathways increased and decreased in short-time treated samples compared to vehicle samples does show upregulation of pathways related to apoptosis and downregulation of the MAPKKK pathway in short-time treated samples.