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. 2021 Jun 15;11(34):21189–21206. doi: 10.1039/d0ra10789a

Summary of studies that evaluated application of ZnO NPs in restorative dentistry.

Formulations NPs Applications Findings Ref.
ZnO NPs incorporated into resin composite – Evaluating the effect of ZnO NPs incorporated into resin composite for the potential one-step treatment of caries lesion – The loading of ZnO NPs on the demineralized dental surface and their infiltration power were significantly improved when ZnO NPs were carried by the resin 88
SYNT–ZnO NPs – Evaluation of the compressive strength and radiopacity of calcium silicate cement containing ZnO NPs – Incorporation of ZnO NPs increased compressive strength and radiopacity 96
ZnO/AgNPs in a composite resin – Application of Ag doped ZnO NPs in a composite resin – The nanospheres of ZnO/Ag lead to a better biofilm inhibition 83
– The nanospheres of ZnO/Ag could be a good option as a new restorative material
Polymerized acrylic resins-ZnO NPs – Evaluation of incorporating zinc oxide NPsto autopolymerized acrylic resins on their flexural strength – The incorporation of zinc oxide NPs has a significant effect on the flexural strength of auto-polymerized acrylic resins 84
ZnO NP–glass ionomer cement – Evaluation of properties of glass ionomer cement reinforced with ZnO NP – Addition of ZnO NPs to type IIa GIC led to a marginal increase in mechanical properties 93
GIC–ZnO NP – Evaluation of the antibacterial activity of zinc oxide NPs incorporated into selfcured glass ionomer cement (GIC) and light-cured resin-reinforced GIC on Streptococcus mutans biofilm – A low concentration of NPs does not improve the antibacterial properties of the GIC 94
ZnO NP–PMMA resin – Evaluation of the antifungal activity of ZnO NPs against Candida albicans – Addition of ZnO NPs to PMMA resin increased antifungal activity 90
PC–ZrO2–ZnO NPs – Evaluating the antibiofilm activity against Enterococcus faecalis and radiopacity, compressive strength of Portland cement (PC) added to zirconium oxide (ZrO2), with ZnO NPs – The addition of nanoparticulated ZnO decreased the compressive strength of PC 97
– All materials presented higher radiopacity and antibiofilm activity than pure PC
– The presence of ZnO (5% or 10%) significantly decreased the compressive strength of the materials
ZnO NP–glass ionomer cement – Evaluating antibacterial and mechanical properties of ZnO NP to the conventional glass ionomer cement – GIC incorporated with 3% w/w concentration of size ZnO NP was the best alternative to conventional GIC for restorative purposes which provides greater antibacterial property 92
– Incorporation of ZnO NPs has no significant difference over the mechanical properties of set glass ionomer cement
Flowable resin composites containing ZnO NPs – Evaluating the physical–mechanical properties and antibacterial activity of resin composites containing ZnO NPs against Streptococcus mutans – The ZnO containing resins show significantly lower depth of cure, and higher bond strength 87
– The flexural strength and compressive modulus remain unchanged by incorporation of NPs
– Compressive strength and flexural modulus significantly increase
– Antibacterial activity significantly increases
Amalgam–Al2O3–ZnO NP – Hardness improvement of dental amalgam using Al2O3–ZnO NP – Al2O3 NPs as filler improved hardness of dental amalgam material 95
– The hardness of Silverfil increased as the percentage of ZnO loading increased
ZnO and ZnO:Ag nano sealers – Evaluation of microleakage and antibacterial properties of prepared ZnO and ZnO:Ag nano sealer – Ag doped ZnO nanopowders for using as sealer exhibit better microleakage and antibacterial properties comparing to common sealer 98
ZnO/MgO nanocomposite in zinc polycarboxylate dental cement – Characterization of NPs and nanocomposite of ZnO and MgO for zinc polycarboxylate dental cement preparation – The zinc polycarboxylate dental cements obtained by synthesized nano-scale powders revealed excellent mechanical strength 89
– Zinc polycarboxylate dental cement had higher strength than conventional Harvard and Adhesor zinc polycarboxylate cements
– Mechanical strength of dental cements was dependent on composition size scale
ZnO-NP-containing composites – Evaluation of the antibacterial effectiveness of ZnO-NPs against Streptococcus sobrinus – An 80% reduction in bacterial counts was observed with 10% ZnO-NP-containing composites 82