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. 2021 Jun 15;11(34):21189–21206. doi: 10.1039/d0ra10789a

Summary of studies that evaluated application of ZnO NPs in oral implantology.

Formulations NPs Applications Findings Ref.
ZnO NPs – Evaluate the antibacterial activity of ZnO NPs against isolates from internal cavity of dental implant – ZnO NPs were effective against bacteria isolated from internal cavity of dental implant 128
ZnO NPs–Ti films on Si substrates – Evaluate the antibacterial and biocompatible nanocomposite for dental implant applications – The strongly inhibit the growth of both Staphylococcus aureus and Escherichia coli observed 124
– The superior adhesion and proliferation ability on the nC–titania–zinc-oxide coated substrates as compared to uncoated ones observed
ZnO NPs deposited on Ti – Evaluate the corrosion resistance of ZnO NPs deposited on commercial pure titanium implants – ZnO functionalized samples have improved anti-corrosive properties 122
PEEK/ZnO composites Enhancing the mechanical performance of poly(ether ether ketone)/ZnO nanocomposites to provide promising biomaterials for orthopedic implants – PEEK/ZnO composites were good candidates for orthopedic materials and trauma implants 127
PSA–ZnO–SiO2–DMH NPs on Ti implant – Enhancing antibacterial ability of Ti implants against both Pseudomonas aeruginosa (P. au), Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) – Novel surface system provided a promising self-antibacterial bioplatform for metallic implants without using antibiotics 103
ZnO on carbon nanotubes/chitosan modified Ti Biofunctionalization of carbon nanotubes/chitosan hybrids on Ti implants deposited ZnO nanostructures – CNTs can strengthen the antibacterial activity against E. coli and S. aureus by 8% and 39%, respectively 129
– CS can improve the cytocompatibility of CNTs and ZnO
ZnO NPs-hydroxyapatite coated onto Ti discs – Determine the antibiofilm activity of nanoparticulate coated titanium (Ti) dental implant as coating materials – Coating Ti dental implant surfaces with ZnO NPs to provide an antimicrobial function 120
ZnO NPs and nanohydroxyapatite onto the surface of glass substrates – ZnO NPs material for dental implants to inhibit bacterial adhesion and promote osteoblast growth – 100% ZnO NPs and 75% ZnO NPs/25% nanohydroxyapatite composite coated substrates have significant antimicrobial activity 123
– ZnO NPs can, on its own, provide an optimal coating for future bone implants that are both antimicrobial and biocompatible
Graphene/ZnO nanocomposite – The potential of graphene/ZnO nanocomposite (GZNC) film protects dental implant surfaces against the cariogenic properties of Streptococcus mutans – Significant reduction in biofilm in the presence GZNC 118
– The anti-biofilm behavior of artificial acrylic teeth surfaces coated with GZNC – The potential of GZNC as an effective coating agent for dental implants by efficiently inhibiting S. mutans biofilms
Coated implants with ZnO and WO3 NPs – Evaluate the antibacterial activity against Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis and Pseudomonas aeruginosa – ZnO was more bactericidal than WO3 121