Chemical structures of natural isoflavones and IC₅₀ values obtained against mushroom tyrosinase.

Compound no.	Compound name	Chemical structures	IC50 values (μM)	Reference
91	Daidzein		17.50	30
92	7,3′,4′-Trihydroxyisoflavone		52.3	135
93	7,8,4′-Trihydroxyisoflavone		11.21	135
94	3,8-Dihydroxy-9-methoxy pterocarpan		16.7	141
95	3′-Hydroxygenistein		15.9	168
96	6-Hydroxydaidzein		0.009	58
97	Calycosin		1.45	180
98	Cajanin		67.9	58
99	Daidzein-7-O-β-glucopyranose		22.2	58
100	5-Hydroxy-daidzein-7-O-β-glucopyranose		4.39	58
101	7-(b-Glucopyranosyl)-2′-hydroxygenistein		729	58
102	(8,9)-Furanyl-pterocarpan-3-ol		7.18	50
103	Neorauflavane		500	78
104	3′-Hydroxy-8-methoxy vestitol		67.8	50
105	Khrinone B		54.0	50
106	7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one		45.8	48
107	7,8-Dihydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one		53.9	48
108	3-(3,4-Dihydroxyphenyl)-8-hydroxy-7-methyl-4H-chromen-4-one		129.9	48
109	7,8-Dihydroxy-3-(3-hydroxyphenyl)-4H-chromen-4-one		96.4	48
110	7,8-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one		50.9	48
111	7,8-Dihydroxy-3-(2-methoxyphenyl)-4H-chromen-4-one		82.8	48
112	6,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one		8.1	68
113	6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one		15.6	68
114	5,7-Dihydroxy-3-(2-methoxyphenyl)-4H-chromen-4-one		171.1	68
115	7-Hydroxy-3-(3-hydroxyphenyl)-4H-chromen-4-one		110.9	68
116	3-(4-Hydroxyphenyl)-7-methyl-4H-chromen-4-one		38.1	68
117	5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one		141.3	68
118	6-Hydroxy-3-(4-hydroxyphenyl)-7,8-dimethyl-4H-chromen-4-one		45.8	68
119	6-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one		83.5	68
Standard	Kojic acid		89	48, 68, 135 and 141