Chemical structures of natural chalcones and IC50 values obtained against mushroom tyrosinase.
| Compound no. | Compound name | Chemical structures | IC50 values (μM) | Reference |
|---|---|---|---|---|
| 24 | 2,4,2′,4′-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone (TMBC) |
|
0.95 | 118 |
| 25 | 2,2′,4,4′-Tetrahydroxychalcone |
|
0.07 | 113 |
| 26 | Isoliquiritigenin |
|
4.85 | 36 |
| 27 | Kuwanon J |
|
0.17 | 36 |
| 28 | Kuraridin |
|
0.6 | 27 |
| 29 | Isobavachromene |
|
15.8 | 134 |
| 30 | Morachalcone A |
|
0.14 | 112 |
| 31 | 4′-O-Methylbavachalcone |
|
48.8 | 134 |
| 32 | 4'-(p-Toluenesulfonylamino)-4-hydroxychalcone |
|
23.3 | 36 |
| 33 | Isovabachalcone |
|
12.3 | 134 |
| 34 | Artocarmitin C |
|
20.6 | 135 |
| 35 | Flavokawain B |
|
14.38 | 29 |
| 36 | Flavokawain A |
|
14.26 | 29 |
| 37 | Xanthohumol |
|
15.4 | 30 |
| 38 | 4′-O-Methylxanthohumol |
|
34.3 | 134 |
| 39 | Xanthohumol C |
|
41.3 | 30 |
| 40 | Xanthoumol B |
|
46.7 | 30 |
| 41 | Flavokawain C |
|
106.7 | 29 |
| Standard | Kojic acid |
|
89.5 | 29, 30, 134 and 135 |