Fig. 3.

Transcriptionally deregulated lipidomic processes are different in HCC compared to CCA.

The alteration in gene expression profiles of tumour vs. surrounding tissue in HCC (first arrow) and CCA (second arrow). The upregulated genes are marked with red ↑, and downregulated with ↓. ACLY, acetyl-CoA by ATP citrate lyase; ACC, acetyl-CoA carboxylase; BA, bile acids; CCA, cholangiocarcinoma; Chol, cholesterol; DGAT1/2, diglyceride acyltransferase 1 and 2; DNL, de novo lipogenesis; ELOVLs, elongation of very-long-chain fatty acids; FADS2, fatty acid desaturase 2; FAO, fatty acid oxidation; FASN, fatty acid synthase; FATPs, fatty acid transport proteins; FFA, free fatty acids; HCC, hepatocellular carcinoma; HMGCR, 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase; LPL, lipoprotein lipase; MUFA, monounsaturated FA; PUFA, polyunsaturated FA; SCD, stearoyl-CoA desaturase; SQLE, squalene epoxidase; TG, triglyceride.