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. 2022 Apr 2;60:101491. doi: 10.1016/j.molmet.2022.101491

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Identification of SDC4 as an exercisetraining-responsivehepatokine. (A) Identification of proteins only secreted from hepatocytes derived from Sedentary and Exercise-trained mice. (B) The percentage of classically and non-classically secreted proteins secreted from hepatocytes derived from Sedentary and Exercise-trained mice. (C) Classically secreted hepatokines derived from hepatocytes of Sedentary and Exercise-trained mice. (D)Sdc4 mRNA in the livers of Sedentary and Exercise-trained mice. Data are presented as mean ± SEM, with n = 7–8 per group. ∗P < 0.05 vs. Sedentary. Significance was assessed by students two tailed unpaired t-test (panel D).