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Mice were treated with 25-mg/kg bedaquiline, 2.5-mg/kg delamanid, and 100-mg/kg linezolid 5 times per week. Bedaquiline (A), N-desmethyl bedaquiline (B), delamanid (C), DM-6705 (D), and linezolid © plasma concentration-time profiles after 4 weeks of bedaquiline, delamanid, and linezolid therapy in tuberculosis-infected BALB/c mice. Plasma concentrations are plotted as mean and standard errors of the mean for 2 mice per study drug per time point.
