Table 1.
Results of Pharmacokinetic Analysis (n = 2 per Time Point)
| Drug | T max, h | C max, range, ng/mL | AUC0–24, mean (SEM), ng/mL⋅h) |
|---|---|---|---|
| Bedaquiline (25 mg/kg) | 1.00 | 1920–1310 | 19 661 (1121) |
| N-Desmethyl-bedaquiline | 0.75 | 5960–8700 | 111 273 (6312) |
| Delamanid (2.5 mg/kg) | 0.75 | 864–1080 | 11 234 (841.7) |
| DM-6705 | 0.25 | 18.9–23.7 | 352.4 (34.9) |
| Linezolid (100 mg/kg) | 2.00 | 90 500a | 251 269 (14 931) |
Abbreviations: AUC0–24, 24-hour area under the receiver operating characteristic curve; Cmax, maximum plasma concentration; SEM, standard error of the mean; Tmax, time to maximum plasma concentration.
aFor linezolid, the drug concentration was assessed in only 1 mouse.