Table 4.

Topic communities related to tyrosine kinase inhibitor (TKI) research.

Community	Wordsa
C1-64	“Non-small cell lung cancer”; “EGFR”; “EGFR-TKI”; “EGFR mutation”; “lung cancer”; “erlotinib”; “osimertinib”; “gefitinib”; “lung adenocarcinoma”; “mutation”; “resistance”; “afatinib”; “drug resistance”; “T790M”; “brain metastasis”; “acquired resistance”; “next-generation sequencing”; “adenocarcinoma”; “T790M mutation”; “circulating tumor DNA”; “icotinib”; “liquid biopsy”; “epithelial-mesenchymal transition”; “EGFR-TKI resistance”; “sequencing”; “small cell lung cancer”; “case report”; “bevacizumab”; “gefitinib resistance”; “pemetrexed”; “squamous cell carcinoma”; “KRAS”; “epidermal growth factor”; “real-world study”; “leptomeningeal metastasis”; “advanced NSCLC”; “cost-effectiveness”; “rebiopsy”; “dacomitinib”; “IGF-1R”; “STAT3”; “droplet digital PCR”; “whole-brain radiotherapy”; “pleural effusion”; “BIM”; “uncommon mutation”; “polymorphism”; “Met amplification”; “first-line treatment”; “EGFR exon 20”; “computed tomography”; “cell-free DNA”; “TP53”; “radiosurgery”; “cisplatin; “docetaxel”; “leptomeningeal carcinomatosis”; “skin rash; “exosomes”; “cerebrospinal fluid”; “exon 19 deletion”; “exon 19”; “cetuximab”; “metformin”
C2-97	“Targeted therapy”; “renal cell carcinoma”; “sunitinib”; “chemotherapy”; “cancer”; tumor”; “metastasis”; “sorafenib”; “prognosis”; “pazopanib”; “hepatocellular carcinoma”; “lenvatinib”; “apatinib”; “immunotherapy”; “toxicity”; “metastatic renal cell carcinoma”; “radiotherapy”; “VEGF”; “progression-free survival”; “biomarker”; “angiogenesis”; “overall survival”; “adverse event”; “carcinoma”; “meta-analysis”; “sarcoma”; “VEGFR2”; “oncology”; “cabozantinib”; “renal cancer”; “VEGFR-TKI”; “PD-L1”; “VEGFR”; “clinical trial”; “axitinib”; “immune checkpoint inhibitor”; “molecular targeted therapy”; “thyroid cancer”; “FGFR”; “PDGFR”; “Phase I clinical trial”; “cardiotoxicity”; “vandetanib”; “regorafenib”; “angiogenesis inhibitor”; “PD-1”; “ovarian cancer”; “colorectal cancer”; “hypertension”; “anlotinib”; “bone metastasis”; “microRNA”; “recurrence”; “soft tissue sarcoma”; “mTOR”; “hypoxia”; “anti-angiogenesis”; “nivolumab”; “prognostic factor”; “AXL”; “RET”; “phase II clinical trial”; “everolimus”; “melanoma”; “anaplastic thyroid cancer”; “differentiated thyroid cancer”; “receptor TKI”; “clear cell renal cell carcinoma”; “medullary thyroid cancer”; “cancer therapy”; “mTOR inhibitor”; “kidney”; “adjuvant”; “tumor microenvironment”; “solid tumor”; “treatment response”; “multitargeted TKI”; “neutrophil-lymphocyte ratio”; “toceranib”; “multikinase inhibitor”; “antiangiogenic therapy”; “monoclonal antibody”; “sequential treatment”; “osteosarcoma”; “neoplasm metastasis”; “tolerability”; “esophageal cancer”; “hypothyroidism”; “circulating tumor cell”; “neoadjuvant therapy”; “Met TKI”; “PDGF”; “paclitaxel”; “neuroblastoma”; “oligoprogression”; “cervical cancer”; “pembrolizumab”
C3-46	“chronic myeloid leukemia”; “imatinib; dasatinib”; “BCR-ABL”; “nilotinib”; “gastrointestinal stromal tumor”; “acute myeloid leukemia”; “leukemia”; “molecular response”; “ponatinib”; “acute lymphoblastic leukemia”; “Philadelphia chromosome”; “TKI resistance”; “FLT3”; “kit”; “quality of life”; “adherence”; “head and neck squamous cell carcinoma”; “imatinib resistance”; “stem cell transplantation”; “leukemia stem cell”; “bosutinib”; “stem cell”; “Ph+ALL”; “treatment-free remission”; “protein kinase inhibitor”; “pulmonary arterial hypertension”; “minimal residual disease”; “PDGFRA”; “discontinuation”; “T315I”; “adverse drug reaction”; “chronic phase”; “cytokine”; “interferon”; “c-Kit”; “midostaurin”; “single nucleotide polymorphism”; “ruxolitinib”; “BCR-ABL mutation”; “kit mutation”; “treatment discontinuation”; “rechallenge”; “Src tyrosine kinase”; “BCR-ABL TKI”; “patient-reported outcome”
C4-38	“HER2”; “apoptosis”; “breast cancer”; “lapatinib”; “autophagy”; “combination therapy”; “neratinib”; “c-Met”; “gastric cancer”; “glioblastoma”; “AKT”; proliferation”; “nanoparticles”; “ERK”; “pancreatic cancer”; “reactive oxygen species”; “cancer stem cell”; “chemoresistance”; “Src”; “hepatotoxicity”; “oxidative stress”; “cell cycle”; “pyrotinib”; “radiation”; “PI3K”; “mitochondria”; “trastuzumab”; “migration”; “NF-kappa B”; “gemcitabine”; “drug delivery”; “glioma”; “triple-negative breast cancer”; “diarrhea”; “adjuvant therapy”; “metastatic breast cancer”; “PI3K/AKT”; “invasion”
C5-37	“Pharmacokinetics”; “ibrutinib”; “metabolism”; “molecular docking”; “plasma”; “drug-drug interaction”; “P-glycoprotein”; “therapeutic drug monitoring”; “Bruton tyrosine kinase”; “BTK inhibitor”; “nintedanib”; “chronic lymphocytic leukemia”; “positron emission tomography”; “LC-MS/MS”; “personalized medicine”; “anticancer”; “lymphoma”; “breast cancer resistance protein”; “interstitial lung disease”; “spleen tyrosine kinase”; “multidrug resistance”; “molecular dynamics”; “antitumor”; “lung”; “inflammation”; “diabetes”; “anticancer drug”; “BCL-2”; “bioavailability”; “synthesis”; “human plasma”; “mantle cell lymphoma”; “idiopathic pulmonary fibrosis”; “virtual screening”; “UPLC-MS/MS”; “pulmonary fibrosis”; “blood-brain barrier”
C6-14	“ALK”; “crizotinib”; “Met”; “receptor tyrosine kinase”; “ROS1”; “ALK-TKI”; “alectinib”; “ALK rearrangement”; “immunohistochemistry”; “lorlatinib”; “BRAF”; “ceritinib”; “resistance mutation”; “brigatinib”

^aKeywords in each community are listed in descending order of frequency.