Fig. 2.

Spatial heterogeneity of immune microenvironment. Tumor immune microenvironment was reported that can be broadly divided into immune-hot or -cold based on whether it favor an effective anti-tumor immune response or not. Representative traits of a heterogeneous immune microenvironment including the spectrum of neoantigen, the infiltration of immunological suppressive cells and effector cells, the status of vasculature, the milieu of cytokine/nutrient and metabolic program