FIG. 1.

CFU enumeration in the lungs, livers, and spleens of infected mice treated with HNP-1. Mice were infected with 1.5 × 10⁴ M. tuberculosis H₃₇Rv organisms via the tail vein. HNP-1 at 1 (□) and 5 μg per mouse was given subcutaneously for 1, 2, and 4 weeks (▪, control). Seven days after the completion of therapy, CFU were enumerated in lungs (a), livers (b), and spleens (c). Error bars represent standard deviations for four animals in each group at each time point. The statistical analysis was performed by two-way analysis of variance. ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001.