Table 2.

Comparison of OCTA Metrics Between Diabetic Eyes Without Clinical Signs of Diabetic Retinopathy and Healthy Controls Using Univariate Analysis

	Normal Controls (52 Eyes, Mean ± SD)	Diabetic Eyes Without Clinical Signs of DR (49 Eyes, Mean ± SD)	P Value
FAZ associated parameters (3 mm × 3 mm)
FAZ area, mm2	0.35 ± 0.10	0.32 ± 0.11	0.211
FAZ perimeter, mm	2.38 ± 0.39	2.28 ± 0.40	0.197
AI	1.15 ± 0.06	1.14 ± 0.04	0.932
FD-300	51.18% ± 3.16%	48.90% ± 3.45%	0.001*
Superficial retinal layer (3 mm × 3 mm)
VD_all	45.70% ± 4.96%	44.37% ± 4.24%	0.602
VD_central	29.30% ± 4.46%	28.89% ± 5.04%	0.160
VD_temporal	46.88% ± 5.07%	45.80% ± 4.49%	0.676
VD_superior	48.14% ± 5.26%	46.54% ± 0.04%	0.091
VD_inferior	47.42% ± 6.05%	46.13% ± 0.04%	0.267
VD_nasal	47.32% ± 4.78%	45.87% ± 0.04%	0.616
EAA, mm2	0.0009 ± 0.0016	0.0032 ± 0.0093	0.148
VLF	0.07 ± 0.01	0.07 ± 0.01	0.676
Fractal dimension	1.75 ± 0.01	1.75 ± 0.02	0.716
VDI	7.01 ± 0.241	7.08 ± 0.29	0.229
Deep retinal layer (3 mm × 3 mm)
VD_all	47.88% ± 4.17%	47.41% ± 4.76%	0.796
VD_central	20.36% ± 4.72%	21.80% ± 5.48%	0.160
VD_temporal	50.00% ± 4.25%	49.61% ± 5.04%	0.817
VD_superior	51.45% ± 4.87%	50.85% ± 5.89%	0.760
VD_inferior	51.55% ± 5.19%	50.37% ± 5.46%	0.236
VD_nasal	49.67% ± 4.72%	49.17% ± 5.34%	0.957
EAA, mm2	0.0003 ± 0.0014	0.0005 ± 0.0017	0.411
VLF	0.08 ± 0.01	0.08 ± 0.01	0.128
Fractal dimension	1.75 ± 0.01	1.75 ± 0.01	0.114
VDI	5.49 ± 0.10	5.51 ± 0.12	0.932
Peripapillary RPCP (4.5 mm × 4.5 mm)
VD-whole area	50.43% ± 7.34%	47.64% ± 7.99%	0.070
VD-temporal	55.20% ± 6.75%	52.15% ± 8.07%	0.065
VD-superior	49.12% ± 8.31%	46.73% ± 8.81%	0.164
VD-inferior	50.09% ± 8.16%	46.78% ± 8.39%	0.047*
VD-nasal	46.71% ± 8.30%	44.29% ± 8.64%	0.153
VLF	0.07 ± 0.01	0.07 ± 0.01	0.052
Fractal dimension	1.68 ± 0.02	1.67 ± 0.03	0.024*
VDI	8.05 ± 0.41	8.21 ± 0.48	0.053

SD, standard deviation; AI, acircularity index; VD, vessel density.

^* P < 0.05 was considered a statistically significant difference between the groups.