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. 2022 Apr 21;66:10.29219/fnr.v66.8224. doi: 10.29219/fnr.v66.8224

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© 2022 Tian Su et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

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Fig. 4 — Resveratrol decreases Hsp60 through SIRT1 regulation. (a) The mRNA level of Hsp60 was decreased. (b) Resveratrol decreased Hsp60 expression. (c) Inhibition of SIRT1 activity increased Hsp60 expression. (d) Hsp60 was decreased in SIRT1-OE cells. The pooled data are shown here as the mean ± SEM, and the significant differences compared to the control cells are shown by P < 0.05 (*). (e) Hsp60 was increased in SIRT1-KD cells. (f) Effects of knocking down Hsp60 on Akt and p53 protein expression.