Table 4.
Association between baseline kidney function and incident cognitive impairment no dementia and dementia
| Characteristic | n | Hazard Ratio, 95% Confidence Interval | P Value |
|---|---|---|---|
| eGFR (per 10-U decrease) | |||
| CIND | 2777 | 0.98 (0.95 to 1.01) | 0.15 |
| Dementia | 563 | 0.95 (0.89 to 1.01) | 0.08 |
| UACR (≥3 versus <3) | |||
| CIND | 2721 | 1.19 (1.07 to 1.33) | 0.001 |
| Dementia | 557 | 1.32 (1.06 to 1.66) | 0.02 |
| UACR (+two-fold) | |||
| CIND | 2721 | 1.07 (1.03 to 1.11) | 0.001 |
| Dementia | 557 | 1.13 (1.05 to 1.23) | 0.002 |
All models were adjusted for age, sex, education (<12 and ≥12 years), diabetes, treatment group, hypertension, and race (White/Australia, White/United States, Black, Hispanic, and other). CIND, cognitive impairment no dementia; HR, hazard ratio; UACR, urine albumin-creatinine ratio.