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. Author manuscript; available in PMC: 2022 Apr 23.
Published in final edited form as: Mol Cell. 2006 Nov 17;24(4):559–568. doi: 10.1016/j.molcel.2006.10.025

Figure 7.

Figure 7

A Model for Nucleosome Remodeling

(i) Unbound state. (ii) The remodeler (Rem) binds the nucleosome (Nuc) in a pocket. (iii) The ATPase/translocase subunit (Tr) engages nucleosomal DNA at a position flanking the dyad, forming a small bulge near the dyad. (iv) Subsequent processive translocation generates large intranucleosomal DNA loops that have three possible fates: forward propagation (resulting in nucleosome jumping [v]), active reverse translocation, or DNA sliding (which may reflect the disengagement of the translocase subunit). Alternatively, the translocation can lead to immediate nucleosome sliding, as indicated by the dashed line, without large loops having been accumulated (from state [iii] to state [v]). (v) Following a remodeling cycle, the remodeler may release the nucleosome (from state [v] to state [i]).