TABLE 5.

COMBINED RECOMMENDATION FOR ROSUVASTATIN BASED ON SLCO1B1 AND ABCG2 PHENOTYPE IN ADULTS

	ABCG2 Normal Function	ABCG2 Decreased Function	ABCG2 Poor Function
SLCO1B1 Increased Function	Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. STRONG	Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. MODERATE	Prescribe ≤20mg as a starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. If dose >20mg needed for desired efficacy, consider an alternative statin or combination therapy (i.e., rosuvastatin plus non-statin guideline directed medical therapy)(3). OPTIONAL
SLCO1B1 Normal Function	Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. STRONG	Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. MODERATE	Prescribe ≤20mg as a starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. If dose >20mg needed for desired efficacy, consider an alternative statin or combination therapy (i.e., rosuvastatin plus non-statin guideline directed medical therapy)(3). OPTIONAL
SLCO1B1 Decreased Function OR Possible SLCO1B1 Decreased Function	Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. Prescriber should be aware of possible increased risk for myopathy especially for doses >20mg. STRONG	Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. Prescriber should be aware of possible increased risk for myopathy especially for doses >20mg. MODERATE	Prescribe ≤10mg as a starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. If dose >10mg needed for desired efficacy, consider an alternative statin or combination therapy (i.e., rosuvastatin plus non-statin guideline directed medical therapy)(3).OPTIONAL
SLCO1B1 Poor Function	Prescribe ≥20mg as a starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. If dose > 20mg needed for desired efficacy, consider combination therapy (i.e., rosuvastatin plus non-statin guideline directed medical therapy) (3). MODERATE	Prescribe ≥20mg as a starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. If dose >20mg needed for desired efficacy, consider combination therapy (i.e., rosuvastatin plus non-statin guideline directed medical therapy) (3). MODERATE	Prescribe ≤10mg as a starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. If dose >10mg needed for desired efficacy, consider combination therapy (i.e., rosuvastatin plus non-statin guideline directed medical therapy)(3). OPTIONAL

Rating scheme described in the Supplemental Material