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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Neurochem. 2022 Mar 6;161(2):173–186. doi: 10.1111/jnc.15590

Figure 4. Predictive accuracy of CSF purines relative to death up to 3 days from ICU admission.

Figure 4.

The area under the curve of the receiver operating characteristic curve (AUROC) for GTP (A), GDP (B), IMP (C), and Xanthine (D). (A) GTP presented at a cut-off value of >2.780 µM (indicated by arrowhead) a sensitivity of 66.67%, and 100% of specificity (AUROC: 0.841, p = 0.0237, 95% CI, CL (Confidence Levels): 62.26% to 99.53%, Youden Index (YI) for >2.780 µM = 0.667). CSF GDP (B), IMP (C) and xanthine (D) levels presented AUROC with lower predictive value (p > 0.05). Arrowheads indicate the optimal cut-off point indicated by the Youden criteria, followed by the respective Youden Index (YI) obtained, presented within parenthesis. (Survival n =11 patients, Non-Survival n=6 patients)