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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Clin Pharmacol Ther. 2022 Feb 27;111(5):1004–1006. doi: 10.1002/cpt.2555

Figure 1.

Figure 1.

Nicotine in tobacco products exists in two forms: nicotine freebase (left) and protonated nicotine (right). In water at 25 deg C, the pKa is 8.01 (Figure courtesy of Peyton Jacob III PhD)