Table 2.
Bone parameters are normal in 4-week-old male Girk3−/− mice
| Parameter | WT (SD) | Girk3−/− (SD) | p-value |
|---|---|---|---|
| MicroCT | n=5 | n=7 | |
| Length, mm | 10.80 (0.15) | 10.93 (0.18) | 0.2150 |
| Width, mm | 2.56 (0.05) | 2.58 (0.04) | 0.5075 |
| BV/TV, % | 6.54 (2.65) | 4.95 (1.60) | 0.2228 |
| BMD, gHA/cm3 | 0.33 (0.01) | 0.34 (0.01) | 0.1577 |
| Tb.Th, μm | 54.81 (3.45) | 59.56 (3.86) | 0.0535 |
| Tb.Sp, μm | 301.4 (39.52) | 346.4 (46.55) | 0.1103 |
| Tb.N, n/mm | 1.18 (0.43) | 0.82 (0.23) | 0.0853 |
| Ct.BAr, mm2 | 0.51 (0.04) | 0.52 (0.03 | 0.5660 |
| Ct.TAr, mm2 | 1.40 (0.09) | 1.41 (0.08) | 0.8192 |
| Ct.BAF, % | 36.59 (0.45) | 37.15 (0.97) | 0.2562 |
| Ct.Th, mm | 126.7 (4.96) | 129.6 (5.15) | 0.3472 |
| Ct.TMD, gHA/cm3 | 0.842 (0.029) | 0.845 (0.014) | 0.8480 |
| Polar MOI, mm4 | 0.188 (0.03) | 0.193 (0.02) | 0.7223 |
| Histomorphometry | n=4 | n=4 | |
| OV/BV, % | 4.73 (2.38) | 3.27 (1.34) | 0.3267 |
| Tb.Th, μm | 34.47 (5.53) | 32.28 (4.36) | 0.5570 |
| Tb.Sp, μm | 539.9 (271.2) | 449.2 (127.1) | 0.5674 |
| Tb.N, n/mm | 2.22 (1.42) | 2.18 (0.52) | 0.9607 |
| LS/BS, % | 28.37 (6.11) | 33.30 (7.80) | 0.3582 |
| MAR, μm/day | 4.28 (0.14) | 3.93 (0.97) | 0.4934 |
| BFR/BS, μm3/μm2 | 1.22 (0.28) | 1.29 (0.32) | 0.7420 |
| Ob.S/BS, % | 35.90 (10.61) | 35.11 (9.08) | 0.9136 |
| Oc.S/BS, % | 11.84 (3.45) | 9.52 (4.69) | 0.4558 |