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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Bone. 2022 Mar 18;159:116391. doi: 10.1016/j.bone.2022.116391

Table 3.

Pathways enriched by Genes Upregulated in Girk3−/− chondrocytes

Reactome Pathway p-value FDR DEGs in Pathway
Laminin interactions 1.77e-07 9.18e-05 Col23a1, Col4a5, Col4a6, Lamc3
Anchoring fiber formation 3.45e-07 9.18e-05 Col23a1, Col4a5, Col4a6
Collagen chain trimerization 7.22e-07 1.28e-04 Col23a1, Col4a5, Col4a6
Crosslinking of collagen fibrils 2.21e-06 2.93e-04 Col23a1, Col4a5, Col4a6
Posttranslational protein phosphorylation 3.48e-06 3.69e-04 Apoe, C3, Chrdl1, Cp, Matn3, Trf
ECM proteoglycans 5.46e-06 4.80e-04 Col23a1, Col4a5, Col4a6, Matn1, Matn3
Collagen degradation 1.01e-05 7.70e-04 Col23a1, Col4a5, Col4a6
Collagen biosynthesis and modifying enzymes 5.84e-05 0.004 Col23a1, Col4a5, Col4a6
Regulation of IGF transport and uptake by IGFBPs 2.02e-04 0.012 Apoe, C3, Chrdl1, Cp, Matn3, Trf
Assembly of collagen fibrils and other multimeric structures 2.22e-04 0.012 Col23a1, Col4a5, Col4a6