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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Bone. 2022 Mar 18;159:116391. doi: 10.1016/j.bone.2022.116391

Table 4.

Pathways affected by Genes Downregulated in Girk3−/− chondrocytes

Reactome Pathway p-value FDR DEGs in Pathway
Attenuation phase 1.45e-09 8.99e-07 Hspa1a
HSF1-dependent transactivation 6.65e-09 2.06e-06 Hspa1a
Striated muscle contraction 1.07e-06 2.21e-04 Acta1, Myh8, Myl1, Tnnc2, Ttn
HSF1 activation 1.66e-05 0.003 Hspa1a
Regulation of HSF1-mediated heat shock response 6.54e-05 0.008 Hspa1a, Bub1, Ablim3
Cellular response to heat stress 1.50e-04 0.015 Hspa1a, Bub1, Ablim3
VEGF ligand-receptor interactions 2.21e-04 0.017 Flt1, Kdr, Pgf
VEGF binds to VEGFR leading to receptor dimerization 2.21e-04 0.017 Flt1, Kdr, Pgf