Figure 2: General approaches to functionalization of biomaterials with signaling molecules for delivery of biological cues.
A. Surface coating of biomaterials with adhesive molecules such as fibronectin, laminin, and collagen. B. Biomaterial surface presentation of adhesion peptides such as arginine-glycine-aspartate (RGD) and proline-histidine-serine-arginine-asparagine (PHSRN) peptides via a double-branched platform. C. Sequestration of biomolecule within biomaterial structure via physical interactions. D. Microsphere encapsulation of biomolecules within biomaterial structure.