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. Author manuscript; available in PMC: 2023 Apr 15.
Published in final edited form as: Acta Biomater. 2022 Mar 12;143:26–38. doi: 10.1016/j.actbio.2022.03.014

Table 3.

Natural biomaterials and their applications for in situ regeneration

Biomaterial Structure/shape Bioactive molecules Animal model Outcome Refs.
Collagen Sponge bFGF/gelatin microspheres Dog periodontal defect New vascular and osteogenic tissues & recovery of periodontal ligament [55]
Collagen Sponge — Rabbit skeletal muscle injury Myofiber regeneration [56]
Collagen Hydrogel — Rabbit articular cartilage defect Recruitment of BM-MSCs for cartilage repair [57]
Collagen Hydrogel — Rat renal reperfusion/ischemia Recruitment of renal progenitor/stem cells & recovery of renal function [58]
Collagen Porous bilayer — Rat diaphragm defect Promote cellular in growth and alignment & maturation of blood vessels [59]
Gelatin Scaffold IGF-1 Rat skeletal muscle injury Recruitment & differentiation of Pax7+ progenitor stem cells (Pax7+ cells) for accelerated muscle regeneration [60]
Gelatin Hydrogel rhFGF-2 Mouse bone maxilla defect rhFGF-2 sustained & controlled release for bone formation [61]
Hyaluronic acid (HA) Hydrogel REG peptide embedded in hydrogel Mouse cutaneous wound Accelerated re-epithelialization for skin regeneration [62]