Skip to main content
. Author manuscript; available in PMC: 2023 Apr 15.
Published in final edited form as: Acta Biomater. 2022 Mar 12;143:26–38. doi: 10.1016/j.actbio.2022.03.014

Table 4.

De-cellularized ECM and their applications for in situ regeneration

Biomaterial De-cellularization reagents Animal model Outcome Refs.
Porcine esophageal mucosa 1% trypsin/0.05% EDTA/37 °C/1h; 3% Triton X-100/48h Rat abdmoninal esophagus defect Oesophagal mucosa reconstruction [63]
Porcine dermal tissue 2% sodium deoxycholate/10mM HEPES/24h; DNAse overnight/4C Primate abdominal wall excision repair Repopulation & maturation of vascular cells; transient immune response [64]
Porcine urinary bladder matrix 0.1% peracetic acid; 4% ethanol/2h Dog hemilarynx defect Re-epithelialization; formation of cartilageous structure; normal phonation; scarred regenerated vocal mucosa [65]