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. Author manuscript; available in PMC: 2023 Apr 15.
Published in final edited form as: Acta Biomater. 2022 Mar 12;143:26–38. doi: 10.1016/j.actbio.2022.03.014

Table 6.

Biomolecules with immunomodulatory and/or stem cell homing and differentiation properties for in situ regeneration

Biomolecules Clinical application Refs.
Substance P + heparin Vascular regeneration [36]
SDF-1 + sphingosine phosphate agonist (SEW2871) Skin wound closure [81]
Lipoxin A4 (LxA4) + resolvin D1 (RvD1) M2 macrophage polarization [83]
Interferon-gamma (IFNy) + interleukin 4 (IL-4) Bone formation [84]
Bone morphogenic protein(BMP): BMP-2 + substance P; BMP-2 + SDF-1; BMP-7 + SDF-1 Bone formation; periodontal regeneration [85–87]