Table 2.
Histologic Features in Leiomyoma with Bizarre Nuclei (LM-BN)
| Study | Bell et al, 199416 | Downes & Hart, 199713 | Ly et al, 201419 | Croce et al, 201420 | Ubango et al, 20164,5 | Bennett et al 201757 |
|---|---|---|---|---|---|---|
| Cases (No.) | 56 | 24 | 51 | 59 | 60 | 31 |
| Age range, years (mean) | 40.0 | 40.7 | 42.5 | 45.0 | 40.5 | 46.7 |
| Tumor size, cm (mean) | 8.0 | 4.2 | 6.8 | 7.3 | 7.6 | 9.0 |
| Focal nuclear atypia | NA | 13% | 12% | 25% | 13% | 39% |
| Distribution | ||||||
| Multifocal | NA | 37% | 29% | 44% | 25% | NA |
| Diffuse | NA | 50% | 59% | 31% | 62% | 61% |
| Nuclear atypia density | ||||||
| Low | 0 | 33% | NA | 47% | 5% | NA |
| Med | 45% | 25% | NA | 32% | 62% | NA |
| High | 55% | 42% | NA | 20% | 33% | NA |
| Mitoses/10 HPF | ||||||
| ≤1 | 21% | 13% | 73% | 63% | 8% | NA |
| 1–5 | 61% | 83% | 25% | 32% | 82% | NA |
| 6–9 | NA | 4% | NA | 5% | 10% | NA |
| Tumor cellularity | ||||||
| Low | 11% | 21% | NA | 2% | 5% | 13% |
| Med | 55% | 58% | NA | 53% | 48% | NA |
| High | 34% | 21% | 6% | 45% | 47% | 87% |
| Staghorn vessels | NA | 21% | NA | 34% | 63% | 65% |
| Prominent nucleoli | NA | NA | NA | 32% | 47% | 71% |
| Eosinophilic globules | NA | NA | NA | 64% | 48% | 84% |
| Growth pattern | ||||||
| Pushing | 70% | 96% | 100% | 98% | 92% | 100% |
| Infiltrating | 30% | 4% | 2% | 8 % | ||
| FH alteration | NA | NA | NA | NA | 54% | 55% |
FH, fumarate hydratase; HPF, high-power fields; NA, not available.