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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: J Thromb Haemost. 2022 Feb 27;20(5):1182–1192. doi: 10.1111/jth.15670

Figure 5: Effect of TG2-cross-linked fibrinogen on prolonged LPS-induced inflammatory cytokine release.

Figure 5:

BMDMs were cultured on an uncoated surface, fibrinogen-coated surface, or TG2-cross-linked fibrinogen coated surface for 4 hours then stimulated with 1 ng/mL lipopolysaccharide (LPS) for 6 or 24 h. IL-10 (A), TNFα (B), IL-1β (C), and IL-6 (D) were measured in supernatant using enzyme-linked immunosorbent assay (ELISA), n=4–8. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001