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. Author manuscript; available in PMC: 2022 Oct 7.
Published in final edited form as: Nat Cell Biol. 2022 Apr 7;24(4):513–525. doi: 10.1038/s41556-022-00872-5

Extended Data Fig. 10. A working model.

Extended Data Fig. 10

A model illustrating how the PARP1-CycT1 signaling pathway senses base lesions or strand breaks caused by certain DNA damaging agents and induces CycT1 PARylation to inhibit P-TEFb phase separation and P-TEFb-dependent Pol II elongation.