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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Mar 3;184:114179. doi: 10.1016/j.addr.2022.114179

Figure 2:

Figure 2:

Map of the regulators of HuR at different levels. Transcriptional factor NF-κB and Smad family proteins regulate the transcription of HuR. RNA-binding protein RNPC1 (green, up-regulation) and TTP (red, down-regulation) oppositely regulate the stability of HuR mRNA, while HuR also autoregulates its own mRNA. MicroRNAs that bind to HuR mRNA and suppress the translation of HuR are listed in red rounded rectangle. Post-translational regulators of HuR are listed in rectangles, with enzymes modulating HuR localization and binding affinity in grey rectangles, MDM2 upregulating HuR expression in green rectangle, and E3 ligases promoting HuR degradation in red rectangle.