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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Mar 12;184:114197. doi: 10.1016/j.addr.2022.114197

Figure 2. Micromixers for comparative study of lipid nanoparticle synthesis.

Figure 2.

(A) Segmented-flow micromixer. Two designs were used in the study with varying diameter of ethanol channel. (B) High-pressure micromixer (C) Staggered herringbone micromixer. The micromixer was arranged in nine cycles each containing twelve grooves. (D) Perspective view on channel structures in the herringbone micromixer. (E) Mixture of 10 mg/mL glycerol monooleate in ethanol with 0.222 mg/mL poloxamer 407 in water; Segmented-flow micromixer showed fouling in microchannels (“F”). A selection of corresponding representative intensity weighted particle size distributions (DLS), shown on right. Adapted from Reiwe et. at.71. All the figures are adapted with permission from Elsevier.