Skip to main content
. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Mar 12;184:114197. doi: 10.1016/j.addr.2022.114197

Figure 3. Microfluidics mixers for scalable manufacturing of lipid nanoparticles.

Figure 3.

(A) Microfluidic design used for the Webb et. al. study51. Two micromixers were employed, including parallelization of multiple Staggered herringbone micromixer (SHM) using NanoAssemblr® and toroidal mixer(TrM) using NxGen Blaze™. (B) Production of drug loaded liposomes with different zeta potential using SHM and TrM. (C) Drug release profile from LNPs synthesized using SHM and TrM. (D) Outline of parallel SHM microfluidic device (PMD). 128 SHMs are incorporated in parallel. (E) Fluorescent images of mixing in a channel, showing the red and green plot profiles versus channel distance at the outlet. (F) LNP production rate comparison. Panels D-E are adapted from Shepherd et. al.72. All the figures are adapted with permission from Elsevier and American Chemical Society.