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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Mar 12;184:114197. doi: 10.1016/j.addr.2022.114197

Figure 4. Ribonucleoprotein loaded lipid nanoparticle synthesized using microfluidic device.

Figure 4.

(A) Microfluidic design with solvent inlets for synthesizing RNP-loaded LNPs. The injected buffer helps to mitigate the exposure of RNPs to high concentrations of EtOH. (B) RNP-LNP induces gene knockout tested using FACS in HeLA-GFP cells. (C) Inhibition of HBV by Cas9 RNP-loaded B-9-LNPs. All the figures are adapted from Suzuki et. el.74. All the figures are adapted with permission from Elsevier.