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. 2022 Apr 23;12:6666. doi: 10.1038/s41598-022-10577-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacokinetic behavior of ALT-801 and semaglutide in C57Bl/6J mice following subcutaneous administration. Mice received a single s.c. injection of ALT-801 or semaglutide at 10 nmol/kg and key PK characteristics were calculated. Compared to semaglutide, for ALT-801 the data indicate a longer T_max with a substantially lower C_max and an overall delayed PK envelope, having a similar AUC.