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. 2022 Apr 23;12:6666. doi: 10.1038/s41598-022-10577-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Body weight of treatment groups. DIO-NASH mice were treated daily with vehicle (s.c.), ALT-801 (5 and 10 nmol/kg, s.c.), elafibranor (78 μmol/kg, oral) or semaglutide (10 nmol/kg, s.c.). Body weight was recorded daily. For ALT-801 and semaglutide, rapid body weight decreases occurred within 1–2 weeks and stabilized. Elafibranor (PPAR-α/δ agonist) causes weight loss in rodents but not in clinical trials. On day 63 vehicle animals were mis-dosed with ALT-801 10 nmol/kg, causing a rapid ~ 8% body weight decrease, which resolved over a period of days. ALT-801 treatment (10 nmol/kg) reduced body weight to the lean normal range (~ 30 g; − 25%). Data are expressed as mean ± SEM (n = 11–12). ***p ≤ 0.001 vs. vehicle control.