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. 2022 Apr 23;8:223. doi: 10.1038/s41420-022-00919-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Representative images, volume, and weight of xenografts from mice after treated with CRCSC-exos transmitting miR-17-5p mimic/inhibitor; B–E TNF-α, IL-2, IL-10, and TGF-β contents in mouse serum determined using ELISA 72 h after exosome injection; F the histological characteristics of tumor tissues detected using HE staining; CD4 and CD8 expression in xenografts from mice detected using immunohistochemistry after treated with CRCSC-exos transmitting miR-17-5p mimic/inhibitor. There were five mice in each group. *P < 0.05 vs the miR-17-5p-NC-Exo group; the measurement data were expressed as mean ± standard deviation.