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. 2022 Apr 23;12:6694. doi: 10.1038/s41598-022-10600-6

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat maps showing differences in structural parameters of (A) trabecular bone and (B) subchondral plate in the four anatomical regions defined in both OA and non-OA samples. Patients were grouped according to disease status; all measurements were standardized (subtract mean and divide by standard deviation of non-OA controls) as indicated by z-scores (deeper red indicated higher readout and deeper blue indicated lower readout).