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. 2022 Apr 23;12:6674. doi: 10.1038/s41598-022-10692-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Discovery of asteltoxin, a new EV secretion inhibitor, from fungi extracts using cancer cells engineered to secrete luciferase-labeled EVs. (A) Chemical structure of asteltoxin. (B) HT29/CD63-Nluc cells were treated with different concentrations of asteltoxin for 24 h, and luminescence in the culture medium was analyzed (blue). Simultaneously, cell growth was analyzed using the WST-8 assay (orange). The relative percentages of luminescence were compared to the DMSO control (100%). (C) PC3 expressing CD63-Antares2 cells (PC3/CD63-Antares2) were treated with DMSO or asteltoxin at the indicated concentrations for 24 h, and luminescence in the culture medium was analyzed. Data are presented as the means ± standard deviation for three independent measurements. Statistical analysis was performed using one-way ANOVA. **P < 0.01.