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. 2022 Apr 23;23:20. doi: 10.1186/s12865-022-00493-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Combination therapy shows decrease in total and M2 macrophage recruitment. A Total TAM recruitment through IHC quantification using CD68 (40X, scale bars are 20 μm). B M2 TAM recruitment through IHC quantification using CD163. The average number of positively stained C CD68 (n = 27 FOVs per group) and D CD163 (n = 27 FOVs per group). TAMs were counted per FOV. Then the E ratio of M2 TAMs to total TAMs was calculated. A mixed effects model was used to calculate statistical differences (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001). Plots created in Prism (GraphPad)