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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Cell. 2021 Nov 4;184(23):5807–5823.e14. doi: 10.1016/j.cell.2021.10.006

Figure 4. Kr-h1 binds to caste-biased genes.

Figure 4.

(A) Proportion of Kr-h1 peaks (fold over input > 3) within genomic features. For global peak distribution, data from worker and gamergate brains were combined.

(B) Overlap of genes bound by Kr-h1 and differentially expressed between workers and gamergates (Fig. 1A). P-value is from a Fisher’s exact test.

(C) Tracks for Kr-h1 occupancy in mature worker and gamergate brains. P-values are from DiffBind. To the right are expression levels (DESeq2-normalized counts). Bars represent the mean + SEM. P-values are from Student’s t tests. ChIP-seq data are from 5 biological replicates per caste. RPM, reads per million.

(D) Top: heatmap for Kr-h1 ChIP-seq at differentially bound regions ± 1 kb. Bottom: differential expression in worker vs. gamergate brains for genes differentially bound by Kr-h1. P-values are from Mann-Whitney U tests.

(E) Same as (D) but showing differential expression in response to JH3 vs. 20E in vitro (top) or in vivo (bottom).

See also Figure S5 and Table S2.