Fig. 3.

ADAMTS7 TAILS high confidence cleavage sites from independent experiments. Histograms showing the overlap between significantly regulated candidate cleavage sites from the SMC1 (A), SMC2 (C), and HUVEC (E) TAILS experiments. Candidate cleavage sites present in both the WT/EQ and WT/Luc comparisons were consistently associated with ADAMTS7 activity and are defined as high confidence cleavage sites (shown as green dots in Fig. 2). The remaining regulated peptides were significant for one or more condition(s) in the histogram categories. Analysis of the cleavage sites using iceLogo shows the similarities between independent TAILS experiments for SMC1 (B), SMC2 (D), and HUVEC (F). ADAMTS7, A disintegrin and metalloproteinase with thrombospondin motifs 7; HUVEC, Human umbilical vein endothelial cells; SMC, smooth muscle cells; TAILS, terminal amine isotopic labeling of substrates.