Fig. 13.

Representative transmission electron images of ultra- sections in CP rat lung shows a. other pneumocyte type II (PII) has irregular elongated heterochromatic nucleus (n) and atypical vacuolation (V) with degenerative changes of its lamellar bodies (Lb) leaving irregular empty vacuoles(V) in its cytoplasm associated with collagen fibres deposition (C). b. shows thick interalveolar septa with pneumocyte type I (PI) that has heterochromatic and dark stained nuclei (n). Interstitial cell (ic) with irregular elongated heterochromatic nucleus (n) can be observed. Lucent areas can be observed in the alveolar wall (*). c. shows eosinophilic cell with irregular heterochromatic nucleus (n) and electronic dense bodies as crystal like materials (arrowhead). Multiple vacuolations (V) can be observed