Fig. 7.
Effect of SAM and curcumin on methylation of the SCNN1B island zone in CFBE. A Results at the level of single cytosine. B Overall (CpG + non-CpG) DNA methylation. C Cumulative results at the level of CpG cytosines. D Cumulative results at the level of non-CpG cytosines. Statistical significance of differences was evaluated by a contingency table and χ2 test in A) P < 0.0001 (overall and also if CpG (P < 0.0001) e non-CpG (P < 0.0001) were analyzed separately) and by ANOVA followed by Bonferroni’s post test in (B, C and D) *P < 0.05 (for all, sam vs untreated cells (ctr)). sam S-adenosyl methionine, cur curcumin