Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 20;15:4209–4220. doi: 10.2147/IJGM.S357659

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Zhang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Somatic mutations and copy number alterations in PSC. (A) Signatures are displayed according to the 96-substitution classification, with x-axis showed mutation types and y-axis showed the estimated mutations of each mutation type, which are identified by a Bayesian nonnegative matrix factorization (NMF) algorithm. (B) Mutational signatures in our cohort (n=30). Samples are featured by the following: smoking, unknown, deficient mismatch repair (dMMR) (Signature 6), dMMR (Signature 15). (C) Mutational burden and weight stratified by dominant mutational signature and clinical variables. (D) Mutational weight among PSC patients with smoking, unknown feature, dMMR (Signature 6) and dMMR (Signature 15). ***:p < 0.001; ****: p < 0.0001.