TABLE 1.
Baseline characteristics.
| Variable | All | MACE | NO-MACE | p-value |
|---|---|---|---|---|
| (N = 1,050) | (N = 175) | (N = 875) | ||
| Age (years) | 49 ± 16 | 59 ± 15 | 46 ± 17 | <2.2 × 10−16 |
| Male gender (%) | 490 (46.7%) | 115 (65.7%) | 375 (42.9%) | 5.0 × 10−8 |
| Hypertension (%) | 250 (23.8%) | 114 (65.1%) | 136 (15.5%) | <2.2 × 10−16 |
| Diabetes (%) | 83 (7.9%) | 45 (25.7%) | 38 (4.3%) | 0.0016 |
| Smoking (%) | 224 (21.3%) | 96 (54.9%) | 128 (14.6%) | <2.2 × 10−16 |
| Total cholesterol level (mg/dl) | 326 [268–365] | 340 [280–382] | 322 [261–358] | 0.00021 |
| Triglyceride level (mg/dl) | 113 [76–177] | 144 [91–185] | 126 [80–171] | 0.0045 |
| HDL cholesterol level (mg/dl) | 47 [43–51] | 45 [41–49] | 48 [44–52] | 0.0019 |
| LDL cholesterol level (at baseline, mg/dL) | 244 [208–279] | 256 [218–294] | 240 [204–270] | 0.0011 |
| LDL cholesterol level (at follow-up, mg/dL) | 110 [96–120] | 102 [90–116] | 112 [96–121] | 0.0024 |
| Family history of FH and/or premature CVD (%) | 776 (79.9%) | 140 (80.0%) | 636 (72.7%) | 0.055 |
| Pathogenic variants of FH (%) | 777 (74.0%) | 153 (87.4%) | 624 (71.3%) | 1.4 × 10−5 |
| History of CVD (%) | 290 (27.6%) | 141 (80.6%) | 149 (17.0%) | <2.2 × 10−16 |
MACE, major adverse cardiac event; FH, familial hypercholesterolemia; CVD, cardiovascular disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein.